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However, evidence of their effectiveness consists mainly of studies with poor methodologic design.In addition, these drugs have not been proven to be superior to acetaminophen or nonsteroidal anti-inflammatory drugs for low back pain.Although it isn't completely understood, it is believed that its effectiveness in the treatment of schizophrenia, bipolar depression, and bipolar manias is due to its work against the dopamine and serotonin receptors.At very low doses (25-100 mg), quetiapine acts primarily as a histamine receptor blocker (antihistamine) and alpha-adrenergic blocker.Antihistamines, like some allergy medicines, are known to have sedative effects.When the dose is increased ( Interfering with serotonin may also cause drowsiness, so some sedation is also seen at higher doses.

Talk with your doctor and family members or friends about deciding to join a study. Bachert C, Bousquet J, Canonica GW, Durham SR, Klimek L, Mullol J, Van Cauwenberge PB, Van Hammée G; XPERT Study Group. Many times, the tiredness caused by quetiapine disappears as the patient's body adjusts to the medication.It may not entirely go away, and some people are just more sensitive to the side effects.I was on seroquel,600mg, and now the doctor is slowly reducing my dose.I`ve always taken it at night and it has always been very sedating. I`ve been told that it will continue to become less sedating until I reach 50-100mg.I`ve been told that at 50-100mg seroquel can be more sedating then at the higher doses.